Project 2

Paternal aging effects. Role of sperm noncoding RNAs in offspring development and health

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Host Institution:

CSIC-INIA (Madrid,Spain)

Doctoral Candidate: Michela Prestianni

Supervisor: Dr. Alfonso Gutierrez-Adan

Co-supervisors: Dr. Patrick Lonergan | Dr. Sebastian Canovas

Non-academic mentor: Dr. Juan Carlos Martínez

Institution of enrolment:

Other institutions involved/secondments:

Enrolment in Doctoral degrees: UMU (Biology and Technology of Reproductive Health)-UCD (Reproductive Biology)

OBJECTIVES

Evaluate aging effects on F1 male reproductive parameters and assess the sperm ncRNAs expression and characterization.
Analyse the role of sperm ncRNAs on the intergenerational age-related paternal effects in F1 and F2 offspring at early embryo development and health outcomes during adulthood.
Assess the contribution of selected ncRNAs to offspring development effects, and check the use oral antioxidant supplements to reduce negative effects.
Identify specific ncRNAs useful for the selection of fertile bulls.